For analysis of the detect the insertion / deletion (I/D) DNA polymorphism in the intron 16 of the ACE gene coding for the humanangiotensin converting enzyme. The insertion itself corresponds to an alu repetitive sequence.
The angiotensin converting enzyme (ACE) is the most important regulator of the renin/ angiotensin/ aldosteron system (RAAS). The enzyme converts angiotensin 1 into the physiological active form angiotensin 2. Latter one unfolds its vasoconstrictive effect directly into the organs (heart, kidney, vessels). The insertion/ deletion polymorphism in the ACE gene is associated immediately at the circulating ACE level. Therefore the I/D polymorphism influences the risk for cardiovascular complications.